Dr. Peter O. Simon, Jr. is a board-certified vascular and interventional radiologist with advanced training across surgery, vascular and interventional radiology, and neurointerventional radiology. He is the founder and Medical Director of Carolina Endovascular & Interventional, an independent, physician-led practice dedicated to delivering advanced minimally invasive care in a high-quality office-based environment.
Dr. Simon received his medical training at premier academic institutions and completed rigorous postgraduate training that spans general surgery, vascular and interventional radiology, and neurointerventional radiology. This multidisciplinary foundation provides him with a comprehensive understanding of both open and minimally invasive approaches to complex disease, allowing for thoughtful procedural selection and patient-centered decision-making. His clinical expertise includes embolization therapies, peripheral arterial disease, venous disease, spine interventions, and image-guided treatments for complex vascular and oncologic conditions.
Prior to founding Carolina Endovascular & Interventional, Dr. Simon practiced in hospital-based and hybrid academic–private practice environments, where he treated a high volume of complex cases and worked closely with multidisciplinary teams. Throughout his career, he has held leadership roles on multiple hospital and practice committees, contributing to quality improvement initiatives, clinical operations, and strategic planning. His leadership experience reflects a consistent focus on safety, efficiency, and evidence-based care delivery.
Notably, Dr. Simon has served as a principal investigator and leader for clinical research trials—an uncommon role in private practice settings. His involvement in clinical research underscores a long-standing commitment to advancing the field of interventional medicine and maintaining fluency in emerging technologies and techniques. This research background continues to inform his practice philosophy, emphasizing data-driven care, outcome measurement, and continuous improvement.
After years of working within traditional hospital systems, Dr. Simon founded Carolina Endovascular & Interventional to offer a different model of care—one that combines academic-level rigor with the accessibility, efficiency, and personalized experience catered to the comfort of the patient and client. This setting allows procedures to be performed in a purpose-built environment designed for patient comfort, streamlined care, and the highest clinical standards, often resulting in shorter wait times, lower overall costs, and a superior patient experience.
Raised in a military family, Dr. Simon grew up in North Carolina, Colorado, Georgia, and Germany. These experiences shaped his appreciation for structure, adaptability, and service, values that continue to influence both his clinical approach and leadership style. He ultimately returned to North Carolina to build a practice grounded in those principles and to serve the communities he now calls home.
As Founder and Medical Director, Dr. Simon remains deeply involved in patient care while also overseeing the clinical, operational, and quality initiatives of the practice. His goal is to provide patients and referring physicians with a trusted, high-value destination for advanced, patient-centered interventional care—delivered with clinical excellence and thoughtful, individualized care.
Publications in Peer-Reviewed Journals
Kelly L, Simon P, Nash A, Thompson J, Affronti ML. “Reducing Recovery Times in Outpatient Liver Biopsies: Role of the GI Nurse.” Gastroenterol Nurs. 2022;45(4):238–243.
Read Article – PubMed
Gray WA, Keirse K, Soga Y, Benko A, Babaev A, Yokoi Y, Schroeder H, Prem JT, Holden A, Popma J, Jaff MR, Diaz-Cartelle J, Müller-Hülsbeck S, and the IMPERIAL investigators. “A Polymer-Coated, Paclitaxel-Eluting Stent (Eluvia) Versus a Polymer-Free, Paclitaxel-Coated Stent (Zilver PTX) for Endovascular Femoropopliteal Intervention (IMPERIAL): A Randomised, Non-Inferiority Trial.” Lancet. 2018;392(10157):1541–1551.
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Meuse MA, Schenk AF, Simon Jr PO, Stackhouse DJ. “Upper-Extremity Subintimal Arterial Flossing with Antegrade-Retrograde Intervention: Thumbs Up.” J Vasc Interv Radiol. 2014;25(8):1306–1308.
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Wang-Gillam A, Plambeck-Suess S, Goedegebuure P, Simon Jr PO, Mitchem JB, Hornick JR, Sorscher S, Picus J, Suresh R, Lockhart AC, Tan B, Hawkins WG. “A Phase I Study of IMP321 and Gemcitabine as the Front-Line Therapy in Patients with Advanced Pancreatic Adenocarcinoma.” Invest New Drugs. 2013;31(3):707–713.
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Spitzer D, Simon Jr PO, Kashiwagi H, Xu J, Zeng J, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure PS, Hotchkiss RS, Mach RH, Hawkins WG. “Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling.” Cancer Res. 2012;72(1):201–209.
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Read Full Text – PMC
Hornick JR, Johnston FM, Simon PO, Younkin M, Chamberlin M, Mitchem JB, Azar RR, Linehan DC, Strasberg SM, Edmundowicz SA, Hawkins WG. “A Single-Institution Review of 157 Patients Presenting with Benign and Malignant Tumors of the Ampulla of Vater: Management and Outcomes.” Surgery. 2011;150(2):169–176.
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Johnston FM, Tan MC, Tan B, Porembka MR, Brunt EM, Linehan DC, Simon Jr PO, Plambeck-Suess S, Eberlein TJ, Hellstrom KE, Hellstrom I, Hawkins WG, Goedegebuure PS. “Circulating Mesothelin Protein and Cellular Anti-Mesothelin Immunity in Patients with Pancreatic Cancer.” Clin Cancer Res. 2009;15(21):6511–6518.
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Johnston FM, Cavataio A, Strasberg SM, Hamilton NA, Simon Jr PO, Trinkaus K, Doyle MB, Mathews BD, Porembka MR, Linehan DC, Hawkins WG. “The Effect of Mesh Reinforcement of a Stapled Transection Line on the Rate of Pancreatic Occlusion Failure After Distal Pancreatectomy: Review of a Single Institution’s Experience.” HPB. 2009;11(1):25–31.
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Simon Jr PO, McDunn JE, Kashiwagi H, Goedegebuure PS, Chang K, Hotchkiss RS, Hawkins WG. “Targeting AKT with the Pro-Apoptotic Peptide, TAT-CTMP: A Novel Strategy for the Treatment of Human Pancreatic Adenocarcinoma.” Int J Cancer. 2009;125(4):942–951.
Read Full Text – PMC
Porembka MR, Doyle MB, Hamilton NA, Simon PO, Strasberg SM, Linehan DC, Hawkins WG. “Utility of the Gyrus Open Forceps in Hepatic Parenchymal Transection.” HPB. 2009;11(3):258–263.
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Kashiwagi H, McDunn JE, Simon Jr PO, Goedegebuure PS, Vangveravong S, Chang K, Hotchkiss RS, Mach RH, Hawkins WG. “Sigma-2 Receptor Ligands Potentiate Conventional Chemotherapies and Improve Survival in Models of Pancreatic Adenocarcinoma.” J Transl Med. 2009;7:24.
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Read Full Text – PMC
Kashiwagi H, McDunn JE, Simon Jr PO, Goedegebuure PS, Xu J, Jones L, Chang K, Johnston F, Trinkaus K, Hotchkiss RS, Mach RH, Hawkins WG. “Selective Sigma-2 Ligands Preferentially Bind to Pancreatic Adenocarcinomas: Applications in Diagnostic Imaging and Therapy.” Mol Cancer. 2007;6:48.
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Lin PW, Simon PO (co-first author), Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. “Paneth Cell Cryptdins Act In Vitro as Apical Paracrine Regulators of the Innate Inflammatory Response.” J Biol Chem. 2004;279(19):19902–19907.
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Gewirtz AT, Simon Jr PO, Schmitt KC, Taylor LJ, Hagedorn CH, O’Brien AD, Neish AS, Madara JL. “Salmonella typhimurium Translocates Flagellin Across Intestinal Epithelia, Inducing a Proinflammatory Response.” J Clin Invest. 2001;107(1):99–109.
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Gewirtz AT, Rao AS, Simon Jr PO, Merlin D, Carnes D, Madara JL, Neish AS. “Salmonella typhimurium Induces Epithelial IL-8 Expression via Ca2+-Mediated Activation of the NF-κB Pathway.” J Clin Invest. 2000;105(1):79–92.
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Book Chapters
Simon Jr PO, Norton PT. Case contributor. Body MRI Cases. Oxford University Press, 2013.
Body MRI Cases – Oxford Academic
Simon Jr PO, Saad WEA. “Ultrasound-Guided Vascular Access.” In: Ultrasound Clinics. 2012;7(3):283–297.
Ultrasound Clinics – Elsevier
Simon Jr PO. “Pre-Arrest Scenarios.” In: ICU Recall, Third Edition. Lippincott Williams & Wilkins, 2008.
Simon Jr PO, Brennan DC, Lowell JA. “Transplantation.” In: The Washington Manual of Surgery. Lippincott Williams & Wilkins, 2007.
Presentations
Middle Eastern Endovascular Therapy Symposia (2018): “Infra-Inguinal Disease: Drug-Eluting Stents.”
Society of Interventional Radiology Annual Scientific Meeting, Distinguished Abstract Plenary Session (2013): “Primary Balloon-Expandable Covered Stents vs. Primary Bare Stents for Chronic Mesenteric Ischemia: Patency and Clinical Outcomes.”
View Published Abstract Record
DOI: 10.1016/j.jvir.2013.01.018
Society of Interventional Radiology Annual Scientific Meeting (2012): “Balloon-Expandable Stent-Grafts for Instent Restenosis in Atherosclerotic Renal Artery Stenosis With Prior Clinical Response.”
View Published Abstract Record
DOI: 10.1016/j.jvir.2011.12.186